An ATPase dependent, radiosensitive acidic microclimate essential for intestinal folate absorption
نویسندگان
چکیده
منابع مشابه
Intestinal Folate Absorption
and 2%, respectively, was converted to 5-AMeFH4. In contrast, less than 4% of the folate transferred across ileal mucosa was 5-MeFH4 when the initial mucosa concentration was 20 nM. Specific activity of dihydrofolate (DHF) reductase, the enzyme responsible for converting PGA to tetrahydrofolic acid, was measured in villus homogenates and was significantly greater in the jejunum than in the ileu...
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Folic acid, or pteroylglutamic acid, is the parent substance of a large group of related compounds called 'folates'. All folate compounds have the same basic molecular structure consisting of three parts: pteridine, para-aminobenzoate (these two together forming a pteroyl group), and L-glutamic acid (Fig. 1). Pteroylglutamic acid itself is a stable, watersoluble compound with a molecular weight...
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Our knowledge on the absorption of folate is incomplete. The deconjugation process as a possible limiting factor in the absorption of folates was investigated. The study also attempted to validate the use of the area under the serum response curve (AUC) from food compared with folic acid as a proxy variable for food folate bioavailability. Folate absorption was determined in healthy ileostomy v...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1978
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1978.sp012368